GEL-50

GEL-50 The active substance in GEL-50 Hyaluronate Sodium, is procduced by a bacterial fermentation process. G Hyaluronic Sodium, is extrated from the capsule of Streptococcus spp. and purified, resulting in a form which is free of protein, pyrogen and nucleic acids.Hyaluronate sodium is the sodium salt of Hyaluronic acid, a non-sulphated acid mucopolysaccharide or glycosaminoglycan of high molecular weight composed of equimolar amounts of D-glucuronic acid and N-acetylglu-cosamine linked together by glycosidic bonds.GEL-50 Sodium pentosan polysulfate (PPS) is a linear polymer prepared from xylan, a complex hemicellulose extract of the plant (Beechwood) origin. PPS is one of the sulfated heparinoid compounds. The heparin-like anti-coagulant effects have been reduced and the anti-inflammatory, fibrinolytic and tissue trophic effects have been enhanced.
PENTOSAN INJECTION actively reverses the effects of osteoarthritis in the joints via a series of actions including:
1. Stimulating Chondrocyte Metabolism: Results in increased production of proteoglycans and healthy cartilage matrix. PPS stimulates synovial fibroblasts and produces an increased amount of high molecular weight hyaluronic acid which results in an increased production of normally viscous joint fluid. Improving the fluid volume and consistency results in more effective joint lubrication and also stabilization, which limits further cartilage damage.
2. Anti-inflammatory Activity: PPS has an inhibitory action on all mediators of the arachidonic acid cascade. PPS also inhibits the lysosomal catabolic enzymes histamine, hyaluronidase, cathepsin B, and polymorphonuclear elastase. PPS exerts a specific inhibitory effect on mediators implicated in the degradation of cartilage matrix components, preserving the cartilage and thus preventing the release of the highly inflammatory mediators, which relieves pain and